In a comprehensive US administrative database from 2005 to 2008, GLP-1-based treatments, particularly sitagliptin and exenatide, were associated with a significantly increased risk of acute pancreatitis-related hospitalization in adults with T2DM [59], thereby reinforcing prior mechanistic experimental studies and spontaneous reports to the FDA suggesting a potential causal relationship
Subscribe to NPR's Health newsletter
Eating some junk food is, of course, perfectly acceptable, but its wise to use portion control to avoid overeating these hard-to-stop foods, especially if GLP-1 medications reduce your appetite
Currently, a phase 3 clinical trial program for retatrutide (TRIUMPH) is underway to assess its safety and efficacy in different obese patient populations, including those with obstructive sleep apnea (OSA), T2D, diagnosed cardiovascular disease, osteoarthritis, and others
But its certainly experienced a resurgence in the past decade
As evidence mounts and patient interest grows, integrating these therapies into everyday practice becomes not just beneficial, but essential